Updated on 24 Jan 2024
We are a multi-disciplinary research laboratory with unquenchable interest and broad expertise in computational biology, protein homeostasis, systems engineering, neuroscience, and evolution. The overarching focus of our research centers on modeling protein homeostasis in health, aging, and neurodegeneration.
We develop and apply computational and systems biology methodology to discover and dissect - across scales from the sequence to the network level - principles of successful protein homeostasis in health, and causes for failure or dysregulation of protein homeostasis in neurodegenerative diseases linked to protein misfolding.
Sebastian trained in engineering, computation, and biology at ETH, the University of Cambridge, and Stanford. He is always most excited to share his enthusiasm for all things proteins and biological systems. Get in touch!
- New paper: "Single-cell expression predicts neuron specific protein homeostasis networks" - now published in Open Biology !
- New paper: "Functional network motifs defined through integration of protein-protein and genetic interactions" - now published in PeerJ !
- Our 3 recent papers appeared in Structure, Nucl Acids Res, and FEBS J !
- Sebastian presents on the computational constraint-based modeling of eukaryotic protein homeostasis at the PRinCE Canada Proteostasis Symposium in Toronto