Publications

  • P do Couto Bordignon, S Pechmann. Inferring translational heterogeneity from ribosome profiling data. bioRxiv , (2019)      
  • ABMSU Hasan, H Kurata, S Pechmann. Improvement of the memory function of a mutual repression network in a stochastic environment by negative autoregulation. BMC Bioinformatics accepted, (2019)      
  • Y Draceni, S Pechmann. Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis. Proc Natl Acad Sci USA 116, 20009-20014 (2019)        
  • S Pechmann. Coping with stress by regulating tRNAs. Sci Signal 11, eaau1098 (2018)    
  • R Geller, S Pechmann, A Acevedo, R Andino, J Frydman. Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate. Nature Communications 9, 1781 (2018)          
  • S Pechmann, JW Chartron, J Frydman. Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo. Nat Struct Mol Biol 21, 1100-5 (2014)        
  • S Pechmann, J Frydman. Interplay between chaperones and protein disorder promotes the evolution of protein networks. PLoS Comput Biol 10, e1003674 (2014)          
  • S Duttler, S Pechmann, J Frydman. Principles of cotranslational ubiquitination and quality control at the ribosome. Mol Cell 50, 379-93 (2013)        
  • S Pechmann, F Willmund, J Frydman. The ribosome as a hub for protein quality control. Mol Cell 49, 411-21 (2013)      
  • F Willmund, M del Alamo, S Pechmann, T Chen, V Albanèse, EB Dammer, J Peng, J Frydman. The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell 152, 196-209 (2013)      
  • S Pechmann, J Frydman. Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding. Nat Struct Mol Biol 20, 237-43 (2013)          
  • A Leitner, LA Joachimiak, A Bracher, L Mönkemeyer, T Walzthoeni, B Chen, S Pechmann, S Holmes, Y Cong, B Ma, S Ludtke, W Chiu, FU Hartl, R Aebersold, J Frydman. The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure 20, 814-25 (2012)      
  • M del Alamo, DJ Hogan, S Pechmann, V Albanese, PO Brown, J Frydman. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. PLoS Biol 9, e1001100 (2011)      
  • S Pechmann, M Vendruscolo. Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation. Mol Biosyst 6, 2490-7 (2010)      
  • S Pechmann, ED Levy, GG Tartaglia, M Vendruscolo. Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins. Proc Natl Acad Sci USA 106, 10159-64 (2009)      
  • GG Tartaglia, S Pechmann, CM Dobson, M Vendruscolo. A relationship between mRNA expression levels and protein solubility in E. coli. J Mol Biol 388, 381-9 (2009)      
  • S Pechmann, ED Levy, GG Tartaglia, M Vendruscolo. Competition between protein aggregation and protein complex formation. BMC Bioinformatics 9, O2 (2008)    
  • M Nishi, J Kobayashi, S Pechmann, M Yamato, Y Akiyama, A Kikuchi, K Uchida, M Textor, H Yajima, T Okano. The use of biotin-avidin binding to facilitate biomodification of thermoresponsive culture surfaces. Biomaterials 28, 5471-6 (2007)      
  • GG Tartaglia, S Pechmann, CM Dobson, M Vendruscolo. Life on the edge: a link between gene expression levels and aggregation rates of human proteins. Trends Biochem Sci 32, 204-6 (2007)      
  • S Lee, M Müller, R Heeb, S Zürcher, S Tosatti, M Heinrich, F Amstad, S Pechmann, ND Spencer. Self-healing behavior of a polyelectrolyte-based lubricant additive for aqueous lubrication of oxide materials. Tribology Letters 24, 217-223 (2006)